ACTA ENDOCRINOLOGICA (BUC)

The International Journal of Romanian Society of Endocrinology / Registered in 1938

in ISI Thomson Master Journal List

January - March 2010, Volume 6, Issue 1
General Endocrinology


Bandyopadhyay R, Chakraborty S

Adrenal corticoids induce pineal gland stimulation associated with adrenocortical inhibition of karyomorphology cell proliferation and hormone milieu in male mice (mus musculus)

Acta Endo (Buc) 2010, 6 (1): 1-14
doi: 10.4183/aeb.2010.1

Background. Pineal and adrenocortical cell morphology, dynamics, hormonal analysis and function in response to both natural and synthetic corticoids awaits in depth\r\ninvestigation in mammals.\r\nAim. To investigate the pineal responsiveness to corticoid treatment from combined morphological and hormonal studies in postpubertal male mice.\r\nMaterial and methods. Three groups, each with 14 mice were used as control (C) or treated with the natural corticoid, hydrocortisone (HYC) at a dose of 4 mg/100 g.b.w. and\r\nsynthetic corticoid, dexamethasone (DEX) at a dose of 4 mg/100 g.b.w. for ten consecutive days.\r\nResults. The treatment induced inverse changes in pineal-adrenocortical karyomorphology, cell proliferation (mitotic percentage M%) and hormonal milieu. Whereas both these corticoids caused pineal stimulation as evidenced from significantly increased nuclear diameter (&#956;m) values (C 3.35 ? 0.05, HYC 4.77 ? 0.02, DEX 4.59 ? 0.04, p<0.001) and cell proliferation (M%) (C 1.11 ? 0.09, HYC 1.59 ? 0.07, DEX 1.44 ? 0.05, p<0.01), the changes induced in adrenocortical nuclear diameter in all the zones (p<0.001),\r\ncell proliferation (M%) (C 1.38 ? 0.05, HYC 0.53 ? 0.06, DEX 0.70 ? 0.05, p<0.001) anddecreased content of adrenal corticosterone (C 0.24 ? 0.03, HYC 0.13 ? 0.01, p<0.001 DEX\r\n0.15 ? 0.02, p<0.01) were those of adrenocortical inhibition.\r\nConclusion. There exists an inverse relationship between the pineal and adrenocortical functions in post pubertal male mice (Mus musculus).

Keywords: adrenal corticoids, pineal, adrenal, nuclear morphology, cell proliferation

Correspondence: Subrata Chakraborty, University of Calcutta - Department of Zoology, 35 Ballygunge Circular Road , Kolkata, West Bengal 700019, India,\r\nE-mail: subratachakraborty2000@yahoo.co.in