October - December 2012, Volume 8, Issue 4

Omar NN, Abdel Maksoud S M, Ali OS

Association of insulin like growth factor 1 (IGF 1) and its binding protein-1 with nephropathy among type 2 diabetes

Acta Endo (Buc) 2012, 8 (4): 539-549
doi: 10.4183/aeb.2012.539

Background. The involvement of IGF 1 in renal pathophysiology has been studied in many details in type 1 diabetes but the role of IGF 1 in early nephropathy in patients with type 2 diabetes is less well characteristic. Objective. To determine whether serum IGF1 and GFBP-1 levels were different between patients with and without diabetic nephropathy and also to investigate the association between them and insulin resistance. Subjects and methods. Insulin resistance (HOMA-IR), IGF 1 and IGFBP-1 were measured in 20 type 2 diabetic patients with nephropathy, 20 type 2 diabetic patients without nephropathy and 15 control subjects. Results. Serum IGF 1 in diabetic nephropathy (333.3 +/-16.44 ng/mL) was significantly higher than in both diabetic patients without nephropathy (133.16 +/- 3.43 ng/mL) and in control subjects (174.33+/-6.23) (P <0.001). A significant negative correlation was observed between IGF 1 and HOMA, (r = -0.72) in diabetic patients without nephropathy and a positive correlation in diabetic nephropathy patients (r = 0.49). Conclusion. High IGF 1 and insulin levels in diabetic nephropathy patients in addition to the significant positive association between IGF 1 and HOMA suggest that both IGF 1 and insulin resistance may play major role in early renal changes in type 2 diabetes.

Keywords: IGF 1, nephropathy, type 2 diabetes, IGFBP-1

Correspondence: Dr. Nesreen Nabil Omar, Al Azhar University, Biochemistry, Cairo, 11371,\r\nEgypt, E-mail: dr.n.nabil@gmail.com