October - December 2012, Volume 8, Issue 4

Aksu O, Ersoy I H,Altuntas A , Koroglu B K,Ciris I M, Tamer M N, Sezer MT

Long term addison disease associated with new onset minimal change disease

Acta Endo (Buc) 2012, 8 (4): 633-638
doi: 10.4183/aeb.2012.633

A 40-year-old woman has been followed up for 19 years by the\r\nendocrinology clinic with the diagnoses of Addison disease and primary hypothyroidism. During the most recent\r\nvisit of the patient, she complained about fatigue and malaise with pretibial edema. In albumin analysis: 2.2 gr/dL and 5.8 g/day proteinuria were detected. In terms of\r\nnephrotic syndrome etiology, renal biopsy was performed and it was considered as minimal change disease. The dose of 7.5\r\nmg/day methyl prednisolone was potentiated to a dose of 1mg/kg/day. During her control, the proteinuria did not regress and 150 mg/day cyclophosphamide was added to the treatment. During the control, her proteinuria regressed from 5.8 r/day to 1.95 mg/day.

Keywords: Adrenal insufficiency, primary hypothyroidism, proteinuria,\r\nminimal change disease

Correspondence: Oguzhan Aksu, MD, ?S?leyman Demirel? University Medical Faculty, Department of Internal Medicine, Isparta, 32000, Turkey, E-mail: droaksu@yahoo.com