January - March 2015, Volume 11, Issue 1

Ademoglu E, Berberoglu Z, Dellal FD, Keskin Ariel M, Kose A, Candan Z, Bekdemir H, Erdamar H, Culha C, Aral Y

Higher Levels of Circulating Chemerin in Obese Women with Gestational Diabetes Mellitus

Acta Endo (Buc) 2015, 11 (1): 32-38
doi: 10.4183/aeb.2015.32

Objective. To characterize serum chemerin levels in obese patients with gestational diabetes mellitus (GDM). Design. Case–control study. Subjects and Methods. Forty seven obese women with newly diagnosed GDM at 24-28 weeks of pregnancy and 32 age, body mass index- and gestational age-matched, normal pregnant women were included. Metabolic patterns and serum chemerin concentrations were measured. Results. Serum chemerin levels were significantly higher in subjects with GDM as compared to healthy pregnant controls (p < 0.05). Fasting insulin was similar between the two groups. HOMA-IR tended to be higher in GDM group but did not reach statistical significance. Women with GDM had significantly higher triglyceride (p < 0.01) and lower highdensity lipoprotein cholesterol (p < 0.001) than controls. In multiple linear regression analyses, chemerin was significantly associated with BMI (beta-coefficient = 0.274, p = 0.01), HbA1c (beta-coefficient = 0.327, p < 0.01), HDL-cholesterol (beta-coefficient = -0.307, p < 0.01), triglyceride (betacoefficient = 0.236, p < 0.05), insulin levels (beta-coefficient = 0.236, p < 0.05) and HOMA index (beta-coefficient = 0.283, p = 0.01). Conclusions. Maternal chemerin levels were significantly increased in GDM at 24-28 weeks of pregnancy. The physiological significance of elevated serum chemerin in GDM remains unclear.

Keywords: chemerin, obesity, gestational diabetes mellitus.

Correspondence: Zehra Berberoglu MD, Ankara Education and Research Hospital, Department of Endocrinology and Metabolism, Sükriye Mh, 06340 Sihhiye, Ankara, Turkey, E-mail: zehraberberoglu@gmail.com