January - March 2018, Volume 14, Issue 1

Yilmaz O, Mevsim V, Kuruoglu E

Development of Clinical Risk Assessment Tool for Osteoporosis (Osteoriskapp) Using a Syndromic Approach

Acta Endo (Buc) 2018, 14 (1): 133-141
doi: 10.4183/aeb.2018.133

Context. DEXA is recommended for osteoporosis screening. However, the rate of screening with DEXA is very low. Therefore, methods that can be used more easily and cost effectively are needed. Objective. The objective of this study is to develop a clinical risk assessment tool of osteoporosis (OSTEORISKAPP) by using syndromic approach. Design. A methodological study was performed. Subjects and Methods. Three hundred and fiftysix participants who are above 50 years old are participants of study and take history and physical examination. Positive likelihood ratio (LR), pre and post test probability, is calculated. A logistic regression analysis and a ROC analysis are made with the model constructed by those criteria. Results. Eighteen different clinical risk indices are diagnosed. According to LR, 4 of these criteria are minimally effective, 11 of them are weakly effective and 3 of them are medium effective criteria According to results of logistic regression analysis, back pain, waist pain, and usage of cortisone for more than 3 months, vertebra tenderness in physical examination, having dorsal kyphosis and being obese are turned out to be statistically significant in 89.9% confidence interval. AUC is found to be 0.948 and diagnostic test is found to have perfect distinction ability. Conclusion. Syndromic diagnostic criteria that will be used for osteoporosis screening of population and that is cost effective, no need to refer, practical, reliable and has tried to be developed.

Keywords: Osteoporosis, clinical risk factors, logistic regression, syndromic approach.

Correspondence: Vildan Mevsim PhD, “Dokuz Eylul” University Faculty of Medicine, Family Medicine, Izmir, 35340, Turkey, E-mail: vmevsim@gmail.com