July - September 2018, Volume 14, Issue 3

Li J, Chen X, Lu X, Zhang C, Shi Q, Feng L

Pregabalin Treatment of Peripheral Nerve Damage in a Murine Diabetic Peripheral Neuropathy Model

Acta Endo (Buc) 2018, 14 (3): 294-299
doi: 10.4183/aeb.2018.294

Context. Peripheral nerve lesions are a major complication of diabetes mellitus, the main clinical manifestations of which are numbness and pain involving the limbs. Objective. To determine the correlation between pregabalin treatment and diabetic peripheral neuropathic pain. Design. An experimental animal study in BALB/c mice. Subjects and Methods. Diabetes models are established by injecting streptozotocin (STZ) into the abdominal cavities of mice. The correlation between the treatment effect, time, and dosage of pregabalin was determined. The effect of a type 1 organic cation transporter (Octn1) in the absorption of pregabalin was evaluated. Results. Pregabalin reduced tactile allodynia in diabetic mice. The best analgesic effect occurred when intestinal absorption was increased. Octn1 mediated pregabalin entry into intestinal epithelial cells, which influenced the absorption of pregabalin with a timedependent fluctuation in the small intestine. Peripheral nerve damage caused by diabetes was dependent on time and dose of pregabalin, which was related to the regular expression of Octn1 in small intestinal epithelium. Conclusions. Peripheral nerve damage caused by diabetes was dependent on time and dosage of pregabalin, which was related to the regular expression of Octn1 in small intestinal epithelium.

Keywords: curative effect, diabetes mellitus, Octn1, peripheral lesion, pregabalin

Correspondence: Lie Feng, Jinan University, The First Affiliated Hospital, Department of Endocrinology, Huangpu Avenue West 613#, Guangzhou, 510632, China, E-mail: ljyyd2008@126.com