![Acta Endicronologica](/Content/images/logo-societatea-romana-endocrinologie.png)
- Login
- Register
- Home/Current Issue
- About the journal
- Editorial board
- Online submission
- Instructions for authors
- Subscriptions
- Foundation Acta Endocrinologica
- Archive
- Contact
![RomanianAcademy](/Content/images/logo-academia-romana.png)
![The Publishing House of the Romanian Academy](/Content/images/eaLogo.gif)
![](/Content/images/mainMenuBottom.gif)
ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List
Acta Endocrinologica(Bucharest) is live in PubMed Central
Journal Impact Factor - click here.
![](/Content/images/headerLogo.gif)
![](/Content/images/current-issue-icon.png)
This Article
Services
Google Scholar
PubMed
Acta Endocrinologica (Buc)
Nicolae C, Nicolae I
Heterogeneity of Gangliosides in Melanocytic Tumors
Acta Endo (Buc) 2012, 8 (1): 17-26doi: 10.4183/aeb.2012.17
Background. Gangliosides are Nacetyl - neuraminic - acid containing glycosphyngolipids that modulate several\r\ncellular functions.\r\nObjective. The present study confirmed the presence of cellular gangliosides in melanocytic tumors with\r\nneuroectodermal origin. These molecules showed large quantitative and structural variability in melanocytic cells.\r\nMethods. The spectrum and levels of gangliosides were performed from 1991 until 2010, in 411 specimens of melanoma, 108 cutaneous metastases of melanoma, 206\r\nnevocellular and dysplastic nevus and 130 specimens of normal skin.\r\nResults. Melanoma showed aberrant gangliosides expression. This included overexpression of normal ganglioside\r\nconstituents (GM2, GM3, GD2, GD3), which also appear in melanocytic nevus and epidermis tissues, and expression of\r\ngangliosides (O-Acetyl-Ganglioside) not found in normal adult tissue. The ganglioside composition of\r\nmelanoma is: GM1 (1,29?0,87%), GM2 (10,32?4,11%), GM3 (22,23?11,30%), GD2 (16,03?9,13%), GD3 (39,06?14,25%), GD1a\r\n(2,16?0,77%), GD1b (1,74?1,01%), GT1b (1,82?1,11 %), GQ1b (1,34?1,07%), OAcetyl-GD3 (4,01?2,81%).\r\nConclusions. The overexpression and variability of gangliosides in melanoma and the low expression of them in normal tissue was correlated with oncogenic process and\r\nmetastatic potential.
Keywords: melanocytic tumors, gangliosides, NANA(N-acetyl-neuraminicacid\r\n)
Correspondence: Corina Nicolae MD, Department of Pharmacology, UMF ?Carol Davila? - Bucharest, Romania, Email: koranik85@yahoo.com