Acta-Endo

Romanian Academy

The Publishing House of the Romanian Academy

Year 2005/

Contents: January - March 2005, Issue 1

January - March 2005, Volume 1, Issue 1

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Articles by Burstein G

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Articles by Burstein G

Acta Endocrinologica (Buc)

Articles by Burstein G

Burstein G

A new hperfractionation effect in the pharmacokinetics of dopaminergic agonist (cabergoline) for the long-term treatment of non-functioning pituitar tumours

Acta Endo (Buc) 2005, 1 (1): 121-125
doi: 10.4183/aeb.2005.121

Using mathematical and clinical trial pharmacokinetics for Cabergoline (a dopaminergic agonist used in hyperprolactinaemia and long-term treatment of nonfunctioning tumours), a new ?hyperfractionation? effect is proven. This effect leads to higher steady state plasma concentrations of drug by fractionating multiple dose regimens in more frequent doses of smaller individual amounts. We generalize this effect by formulating a general mathematical condition for any drug to benefit from hyperfractionation. The effect is important in the long-term treatment of non-functioning tumours as one tries to achieve higher steady state plasma concentrations by using small individual doses in order to insure tolerability. This effect is more complex than the accumulation effect known in pharmacokinetics as a one parameter effect (frequency). Hyperfractionation is a two parameter effect for multiple dose regimens (frequency, dose amount).

Keywords: pharmacokinetics, dopaminergic agonists, pituitary tumours, hyperprolactinaemia

Correspondence: Gabriel Burstein, e-mail: gabrielburstein@yahoo.com

References:
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2. Andreotti AC, Pianezzola E, Persiani S, Paciarni MA, Strolin Beneddetti M, Pontiroli AE. Pharmacokinetics, pharmacodynamics and tolerability of Cabergoline, a Prolactin-lowering drug, after administration of increasing oral doses (0.5,1 and 1.5 mg) in h

3. Burstein G. Four times 0.5 mg is more than two times 1mg: A new hyperfractionation effect in cabergoline pharmacokinetics. P-54, Eighth International Pituitary Congress, New York 2003.

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A new hperfractionation effect in the pharmacokinetics of dopaminergic agonist (cabergoline) for the long-term treatment of non-functioning pituitar tumours

Acta Endo (Buc) 2005, 1 (1): 121-125
doi: 10.4183/aeb.2005.121

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ISSN (print): 1841 - 0987 ISSN (online): 1843 - 066X
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