Acta Endicronologica
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April - June 2005, Volume 1, Issue 2
General Endocrinology

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Acta Endocrinologica (Buc)


Rosianu A, Lazar E, Raica M

Oncoprotein c-erb B2 - prognostic significance in invasive breast cancer

Acta Endo (Buc) 2005, 1 (2): 145-156
doi: 10.4183/aeb.2005.145

Objective: The invasive mammary cancer is the most frequent malignant tumor of a woman. Among the potential prognostic factors are included the biomarkers which measure or are associated with biological processes involved in the tumoral progression.We studied the prognostic importance of the oncoprotein c-erbB2 in the invasive mammary cancer.\r\nMaterials and methods: We included in the study 56 female patients suffering from invasive mammary cancer.The tissue fragments were fitted in formol, included to paraffin, commonly stained with hematoxylin-eosine (HE); for the determination of the c-erbB2 we\r\nused the immunohistochemical method of the avidin-biotin (ABC) complex.\r\nResults: From the total of 56 tumors, 38 (67.9%) presented different degrees of positivity; 18 (32.1%) did not express the oncoprotein c-erbB2.\r\nConclusions: The positivity of oncoprotein c-erbB2 was correlated with the size of the tumor; the carcinomas which are not infiltrative ductal, known as having a better prognostic, were c-erbB2 negative.

Keywords: mammary cancer, oncoprotein c-erbB2, immunohistochemistry

Correspondence: Anca Rosianu, MD, Department of Pathology, University of Medicine and Pharmacy, Timisoara, Romania, e-mail: ancarosianu_muresan@yahoo.com.

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ISSN (print): 1841 - 0987     ISSN (online): 1843 - 066X  
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