Acta Endicronologica
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ACTA ENDOCRINOLOGICA (BUC)

The International Journal of Romanian Society of Endocrinology / Registered in 1938

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July - September 2005, Volume 1, Issue 3
General Endocrinology

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Acta Endocrinologica (Buc)


Naumescu S, Georgescu C, Dragatoiu G, Hazi G, Duncea I, Gozariu L

Studies concerning the correlation between leptin and body composition

Acta Endo (Buc) 2005, 1 (3): 271-280
doi: 10.4183/aeb.2005.271

Introduction: Leptin, which is known to regulate appetite and energy expenditures, may also contribute to mediate the effects of fat mass on the bone.\r\nObjective: The aim of this study was to analyse to what extent leptin and total body composition influence the maintenance of bone mass.\r\nSubjects and methods: We evaluated 34 women divided into two BMI-matched groups based on the ovarian function: 12 premenopausal women, aged 34.08?7.18 years and 22 postmenopausal women aged 61.31?4.51 years, respectively. Total body composition (total fat mass, trunk fat mass and lean mass) and bone mineral density were measured by means of dual-energy X-ray absorptiometry (DXA). Serum leptin concentrations were assessed by ELISA.\r\nResults: The bone mineral content was influenced by both the fat mass (women with normal menstrual cycles r=0.62, p=0.03; postmenopausal women r=0.625, p=0.002) and the trunk fat mass (r=0.597, p=0.004 premenopausal women; r=0.675, p=0.001 postmenopausal women), independently of the ovarian function. Only for the postmenopausal group we could identify a significant correlation between leptin levels and the total body bone mineral density (r=0.479, p=0.024) and the total body bone mineral content (r=0.605, p=0.003), respectively. The serum leptin levels were highly significantly correlated with the total fat mass and the trunk fat mass for both groups. No difference was obtained with regard to the serum leptin levels between pre- and postmenopausal women.\r\nConclusions: Our results suggest the role played by leptin and the fat mass in the maintenance of bone mass.

Keywords: leptin, bone mineral density, bone mineral content, osteoporosis, body composition, menopause

Correspondence: Simina Naumescu, Endocrinology Clinic, Pasteur street, no. 3-5, Cluj-Napoca, email: simina_naumescu@yahoo.com

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ISSN (print): 1841 - 0987     ISSN (online): 1843 - 066X  
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