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January - March 2005, Volume 1, Issue 1
Endocrine Care

Peretianu D

Antithyreoperoxidase antibodies (ATPO) in Hashimoto thyroiditis: variation of levels and correlation with echographic patterns

Acta Endo (Buc) 2005, 1 (1): 61-78
doi: 10.4183/aeb.2005.61

Antithyroidperoxidase antibodies (ATPO), antithyroid antibodies directed to thyroid follicular microsomes, are recognized as the test for diagnosis of Hashimoto?s thyroiditis. The study tries to establish relationships between the ATPO and echographic picture in thyroiditis. In 383 patients (15-85 years, 354 women and 29 men) the antithyroperoxidase assay was performed using ELISA technique, (N= 0 - 34 ?U/ml). Therefore, 185 patients had Hashimoto thyroiditis and 198 patients were excluded. The images obtained from all the patients and controls, classified in 7 patterns, showed that pattern #1 (?hypoechogenic and pseudonodular?) could be considered as pathognomonic for the diagnosis of Hashimoto thyroiditis: the predictive positive value was 95.61%. Five hundred and six evaluation moments echo-ATPO were correlated in both Hashimoto thyroiditis and control group. In patients with Hashimoto thyroiditis, 301 evaluations were performed, both immune (ATPO) and echographic. For all cases and patterns (36 degrees of freedom), &#967;2 test was 77.35. P value was < 0.0001. When ATPO are high, pattern #1 was the most frequent, while for pattern #7 (normal), ATPO should be the lowest. The ATPO evolution can be considered mostly as unchanged during over one year observation. There is no correlation between the ATPO level, echographic pattern and thyroid function: the patients were in the same percent euthyroid and hypothyroid associated with similar echographic patterns. In conclusion, this study shows a highly correlative relationship between the echographic pattern and ATPO levels in Hashimoto patients.

Keywords: Autoimmune disorder, ATPO, Hashimoto?s thyroiditis, thyroid\r\nultrasound /echography, thyroid function

Correspondence: Dan Peretianu, str Povernei no. 32, tel +40.722504098, email:


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