April - June 2008, Volume 4, Issue 2

Baculescu N, Dobrea C, Cordos I, Coculescu M

Graves' disease in a patient with mediastinal B cell non-Hodgkin's lymphoma producing hypercalcemia

Acta Endo (Buc) 2008, 4 (2): 211-222
doi: 10.4183/aeb.2008.211

An increased risk of non-Hodgkin?s lymphoma was found for a personal history of autoimmune conditions: rheumatoid arthritis, systemic lupus erythematosus, celiac disease, autoimmune hemolytic anemia, Crohn?s disease, psoriasis, sarcoidosis and thyroiditis. The associations may not be general but rather for specific non-Hodgkin?s lymphoma subtypes. These non-Hodgkin?s lymphoma subtypes develop during postantigen exposure stages of lymphocyte differentiation, consistent with a role of antigenic drive in autoimmunity-related lymphomagenesis. We present the case of a 30 years old mane, with simultaneous diagnosis of Graves? disease and a huge anterior mediastinal mass which was actually the mediastinal involvement of a diffuse large B-cell lymphoma stage III. The patient had also hypercalcemia, remitted after two courses of chemotherapy. The possible relationship between the two diseases and the role of parathyroid hormone related peptide PTHrP in paraneoplastic syndrome is discussed.

Keywords: non-Hodgkin?s lymphoma, Graves? disease, hyperthyroidism, parathyroid hormone related peptide, hypercalcemia

Correspondence: Mihail Coculescu, Endocrine Department, ?Carol Davila? University of Medicine and Pharmacy, 34-36 Bd. Aviatorilor, 011863, Bucharest, Romania, Phone/Fax: + 40213198718, e-mail: m.coculescu@uni-davila.ro