July - September 2008, Volume 4, Issue 3

Qian S, Huo D, Qian Q

Paraoxonase 1 activity in Northern Chinese diabetic patients with chronic renal failure

Acta Endo (Buc) 2008, 4 (3): 243-249
doi: 10.4183/aeb.2008.243

The objective of this study is to investigate the relationship between paraoxonase 1 (PON1) activity and dyslipidaemia in Northern Chinese diabetic patients with chronic renal failure (DM-CRF). For this purpose, 45 diabetic patients with CRF, 63 non-diabetic patients with CRF, 90 type 2 diabetic patients without CRF were investigated, as well as 70 subjects without diabetes and CRF. The serum PON1 activity and serum lipids, high-density lipoprotein cholesterol (HDLc) were determined. The results showed that, as compared to control subjects, serum ArE1/PON1 activities were significantly decreased in patients with diabetes, CRF and DM-CRF. In a further investigation of the relationship among ArE/PON1 and lipid parameters in all groups, not only serum ArE/PON1 activity, but also ratios of serum ArE/TC and ArE/HDL3c were found to be significantly decreased in the three groups, and the degree of decrement was DM-CRF>CRF>diabetes. In DM-CRF group, multiple regression analysis showed that ArE/PON1 was closely related to HDL2C, Apo A1 and HDLC. ArE/TC was also related to HDL2C, Apo A1, HDLC/TC and HDLC. In conclusion, serum ArE/PON1 can be one of the signals reflecting the disorder of lipid metabolism of CRF, especially in DM-CRF patients.

Keywords: Paraoxonase I, polymorphism, lipoprotein, chronic renal failure, renal transplant

Correspondence: Qingwen Qian, MD, Ph D. Department of Medicine, 1st Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China P.R. phone number: 0086-371-66913360 Email: qwqian@zzu.edu.cn