January - March 2009, Volume 5, Issue 1

Grigorescu F, Attaoua R, Ait El Mkadem S, Beleza S, Bohdanowicz-Pawlak A, Bosch Comas A, Boulton A, Brismar K, Catrina SB, Coculescu M, Escobar-Morreale H, Fica S, Gheorghiu M, Gomis R, Hanzu F, Jobling M, Khusnutdinova E, Milewicz A, Nosicov V, Novialis A, Pasqua, Muller-Wieland D

Haplogendis initiative - SICA

Acta Endo (Buc) 2009, 5 (1): 143-148
doi: 10.4183/aeb.2009.143

In response to increasing interest of the European Commission on large-scale\r\ngenotyping for complex diseases, including variability in ethnic minorities in\r\nEurope (HEALTH-2009-4.3.3-1), at the end of 2008 we composed the\r\nHAPLOGENDIS consortium with partners from Russia and European countries. A\r\nfirst program (SICA) was proposed in cooperation with Russian Federal Agency for\r\nScience and Innovation, focusing on comparative population genetics on diseases\r\naccompanied by insulin resistance. Beside the specificity in analyzing the human\r\ngenome with SNP (single nucleotide polymorphism) and defining haplotype\r\nstructure of genes, the program rises new hypotheses which directly link\r\ncolonization of Europe at the Neolithic period from Eastern Ukraine or Anatolia\r\nwith the development of agriculture and major dietary and life style changes that\r\nmay have an impact on the genome. Although there will be many occasions to\r\nreview both genetic and clinical detailed aspects, this short note will expose some\r\nunifying ideas that joint these partners.

Keywords: HAPLOGENDIS INITIATIVE - SICA

Correspondence: F. Grigorescu, MD, PhD, Molecular Endocrinology, IURC, 641 ave du Doyen\r\nGaston Giraud, 34093 Montpelllier CEDEX5, FRANCE, florin.grigorescu@montp.inserm.fr