April - June 2009, Volume 5, Issue 2

Ilany J, Cohen O

Subclinical central hypothyroidism

Acta Endo (Buc) 2009, 5 (2): 285-292
doi: 10.4183/aeb.2009.285

case of a young woman with cold intolerance is presented. Her thyroid function tests\r\nwere all within the normal range although both TSH and free T4 were in the low normal\r\nrange. The possibility of subclinical central hypothyroidism was raised and tests to confirm\r\nit were performed. The results could be consistent with the diagnosis and treatment with\r\nthyroid hormone was started with clinical improvement. However, with treatment, her TSH\r\nlevel decreased below the normal reference range. We discuss the question of having\r\nhypothyroid symptoms with normal thyroid function tests, should we treat it and how to\r\nevaluate the clinical and laboratory response to treatment in this patient.

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Correspondence: Jacob Ilany, Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer,\r\n52621, Israel, Tel.: 972-3-5305382, 972-5-23852461, Fax: 972-3-6357018\r\nE-mail: jacob.ilani@sheba.health.gov.il