April - June 2011, Volume 7, Issue 2

Siilin H, Ljunggren O, Lundgren E

Primary Hyperparathyroidism and Associated Morbidity during Menopausal Transition - Three Years Follow-up

Acta Endo (Buc) 2011, 7 (2): 249-262
doi: 10.4183/aeb.2011.249

Context. Postmenopausal women are at risk of developing primary hyperparathyroidism (PHPT) and the underlying\r\ndisturbance in calcium homeostasis is suspected to have been established for some time prior to diagnosis.\r\nObjectives. Pre-menopausal women with disturbance in calcium homeostasis suggesting PHPT have been evaluated during\r\nmenopausal transition regarding associated morbidity.\r\nDesign and subjects. Premenopausal women, 40 to 50 years of age, were screened with parameters of calcium homeostasis in\r\nconjunction with routine mammography during 2002-2003. Those who fulfilled preset criteria of mild PHPT (cases) (n=173) were matched to controls (n=193). The pre/perimenopausal\r\nwomen were investigated for the prevalence of PHPT in association with skeletal changes, morbidity and impact on\r\nquality of life (base-line data already published). They have now been re-evaluated regarding different health aspects after three years follow-up.\r\nResults. The cases still had lower bone mineral density (BMD) in total hip, femoral neck and distal third of radius than controls (p<0.05) after three years followup. Time of follow-up, menopausal status, and weight affected BMD independently.\r\nConclusion. Middle-aged women with mild disturbances of calcium homeostasis suggesting early PHPT, had lower BMD in the hip and radius, but the decline in BMD was not accelerated during menopausal transition.

Keywords: Primary hyperparathyroidism, parathyroid hormone, serum\r\ncalcium in premenopausal women, bone mineral density, menopause

Correspondence: Siilin Helene, Surgical Sciences - Department of Surgery, University Hospital of Uppsala, Uppsala 751 85, Sweden email: helene.siilin@surgsci.uu.se