July - September 2011, Volume 7, Issue 3

Gussi I, Ursuleanu A, Ceausu I, Dutescu C, Lazar V, Mirciulescu C

Longer Duration and Lower Fatal Risk of Late-onset Pregnancy-related Ovarian Hyperstimulation Syndrome

Acta Endo (Buc) 2011, 7 (3): 357-363
doi: 10.4183/aeb.2011.357

Background. Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening complication of the luteal\r\nphase or early pregnancy after ovulation induction or ovarian stimulation. The late OHSS form presents an onset more than 10 days after ovulation triggering and is\r\ninfluenced by pregnancy-related HCG secretion.\r\nReport. This paper presents three cases of pregnancy-related OHSS after IVF/ICSI cycles discussing risk factors and management according to European Guidelines.\r\nResults. Individual risk factors are identified such as low BMI, high antral follicle count at the beginning of the ovarian stimulation, high estradiol over 3000 pg/ml.\r\nPatients had moderate OHSS (case 2) and severe OHSS (case 1 and 3). In-patient treatment was 3-14 days. OHSS resolved in\r\nall cases, without manifestations of the critical form.\r\nConclusion. The duration of OHSS is longer in the late form, is pregnancy-related and should be monitored for adverse\r\npregnancy outcomes. However the incidence of fatal risks is low and the treatment is successful.

Keywords: ovarian hyperstimulation syndrome, hematocrit, pregnancy outcome

Correspondence: Ilinca Gussi, MD, Carol Davila University of Medicine and Pharmacy - Obstetrics Cantacuzino Hospital, Bucharest 020633, Romania, email: ilinca.gussi@gmail.com