April - June 2012, Volume 8, Issue 2

Parmar K, Prajapati A, Patel S, Patel M, Patel M

Carioprotective Effects of Lisinopril in Streptozotocin Induced Type-II Diabetic Rats

Acta Endo (Buc) 2012, 8 (2): 177-188
doi: 10.4183/aeb.2012.177

Aim of the study. The objective of the present study was to determine the dose dependent effects of lisinopril, a ACE\r\ninhibitor on cardiovascular complications in streptozotocin induced diabetic rats.\r\nMaterials and methods. Two days old neonatal pups (7?10 g) were used and they were made diabetic by intra-peritoneally (i.p.) injection of 90 mg/kg STZ in citrate buffer solution. Lisinopril was given orally at two different doses of 0.5 mg/kg/day and 3 mg/kg/day, p.o for 8 weeks. After 8 weeks\r\ntreatment biochemical parameters from blood serum and hemodynamic parameters were analyzed.\r\nResults. The significant differences of glucose, insulin, cholesterol, triglyceride, creatinine kinase (CK-MB), lactate dehydrogenase (LDH), CRP level, left ventricular collagen content, cardiac hypertrophy index, left ventricular hypertrophy index in 3 mg/kg/day Lisinopril\r\ntreated group compared to diabetic group were found. It showed a significant decrease in blood pressure compared to diabetic group.\r\nConclusion. Lisinopril has beneficial effects on diabetes and its associated cardiovascular complications.

Keywords: Diabetes mellitus, cardiovascular complications, lisinopril,\r\nlactate dehydrogenase, C-reactive protein, left ventricular collagen content, blood pressure

Correspondence: Kaushal Parmar, Sat Kaival College of Pharmacy, Gujarat Technological University ? Pharmacology, Sarsa, Anand Gujarat, India, email: kkausshall@gmail.com