October - December 2012, Volume 8, Issue 4

Erem C, Civan N

Extensive cerebral calcification and pulmonary bullae in a patient with Ehlers-Danols syndrome

Acta Endo (Buc) 2012, 8 (4): 645-650
doi: 10.4183/aeb.2012.645

We describe a Turkish woman with the association of classical cutaneous features of EDS, extensive cerebral calcification and multiple emphysematous bullae. A 20-year-old woman with a 8-year history of EDS with mild chronic lung disease presented with headache. Physical examination revealed fragility and hyperelasticity of the skin and hypermobility of the joints. A chest computed tomography (CT) showed bilateral paraseptal emphysematous areas and bilateral bullous disease. A cranial CT revealed bilateral extensive calcifications in the cerebral and cerebellar hemispheres and basal ganglia with periventricular and subcortical white matter. Cerebral calcification should be carefully searched for using MRI in patients with EDS and neurological symptoms, such as headache.

Keywords: cerebral calcification, bullous lung, Ehlers-Danlos syndrome

Correspondence: Cihangir Erem, MD, Medical Faculty, Internal Medicine, KTU Tip Fakultesi, Ic Hastaliklari AbD, Trabzon, 61080, Turkey, E-mail: cihangirerem@hotmail.com