April - June 2013, Volume 9, Issue 2

Mocan M, Popa T., Blaga SN

The Influence of Metabolic Syndrome Components on N-Terminal Pro B-Type Natriuretic Peptide Concentrations: The Role of Left Ventricular Diastolic Dysfunction

Acta Endo (Buc) 2013, 9 (2): 229-240
doi: 10.4183/aeb.2013.229

Background. There are few data to demonstrate the usefulness of N-terminal pro B-type natriuretic peptide (NT-proBNP) for the left ventricular diastolic dysfunction (LVDD) diagnosis in metabolic syndrome (MSy) patients as the relationship between NT-proBNP and MSy components is still under study. Objectives. The present study aims to determine the influence of MSy components on NT-proBNP concentrations. In this respect, we tried to identify the relationship between NT-proBNP concentrations and LVDD in patients with MSy and preserved LV systolic function. Methods. 68 hospitalized obese patients with MSy (IDF2006 definition) were taken under study. All patients underwent Doppler echocardiography. NT-proBNP was determined using the ELISA method (Biomedica). The data obtained in the study group were compared to those of 70 obese subjects, age and sex matched, without MSy. Results. The median of plasmatic NT-proBNP level in MSy patients was 155 pmol/L significantly (p=0.002) higher than in the control group (120 pmol/L). Median NTproBNP was significantly higher (p=0.0266) in MSy patients presenting LVDD (160 pmol/L) as compared to those with normal left ventricular function (125 pmol/L).In the LVDD subgroup NT-proBNP level was positively and significantly correlated with age (r=0.326, p=0.025), SBP (r=0.508, p=0.0003) and DBP (r=0.396, p=0.005) and negatively correlated with waist circumference (r=-0.380, p=0.008). Dyslipidemia, impaired fasting glucose and body mass index (BMI) did not significantly influence NT-proBNP levels. Conclusions. MSy patients had higher NT-proBNP concentrations as compared to obese subjects without MSy, due to the presence of LVDD and the positive and statistically significant correlation with age, SBP and DBP.

Keywords: NT-proBNP, Metabolic syndrome, Left ventricular diastolic dysfunction.

Correspondence: Mihaela Mocan MD, UMF "Iuliu Hatieganu" Internal Medicine, Clinicilor 3-5, Cluj-Napoca, 400006, Romania, E-mail: mihaela.mocan@umfcluj.ro