The International Journal of Romanian Society of Endocrinology / Registered in 1938

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July - September 2014, Volume 10, Issue 3

Ionescu-Tîrgoviste C, Gagniuc P.A, , Guja C

A Challenge for the Autoimmune Diabetogenic Mechanisc in Type 1 Diabetes?

Acta Endo (Buc) 2014, 10 (3): 317-328
doi: 10.4183/aeb.2014.317

The pathogenesis of type 1 diabetes became a history longer and longer. There are 40 years since the immunogenetic theory of type 1 diabetes has been launched. Near this anniversary a challenge of this theory was recently published. We give here our interpretation of primary cause of type 1 diabetes which must be connected with the pathogenesis of other phenotypes of diabetes which has a main similar mechanism: the β-cell dysfunction.

Keywords: diabetes, ß-cell, T1D, autoimmune.

Correspondence: Constantin Ionescu-Tîrgoviste MD, PhD, “N.C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, I. Movila 5-7, Bucharest, 020475, Romania, E-mail: