The International Journal of Romanian Society of Endocrinology / Registered in 1938

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January - March 2014, Volume 10, Issue 1
Endocrine Care

Hashemi SB, Sarbolouki S., Djalali M., Dorosty A., Djazayery S.A., Eshraghian M.R., Ebadi A., Sharif M.R., Nikoueinejad H

Adiponectin and Glycemic Profiles in Type 2 Diabetes Patients on Eicosapentaenoic Acid with or without Vitamin E

Acta Endo (Buc) 2014, 10 (1): 84-96
doi: 10.4183/aeb.2014.84

Background. Secreting different adipocytokines, adipose tissue plays an important role in health and disease. Upon omega-3 consumption, changes in the secretion of adipose tissue and its effects on glycemic profile are a controversial subject at the present time. Objectives. We evaluated the effects of eicosapentaenoic acid (EPA) alone and in combination with vitamin E on adiponectin and serum glycemic indices in type II Diabetes patients. Design. This double-blind clinical trial divided all patients randomly into four balanced permuted blocks of EPA, Vitamin E, EPA and vitamin E and placebo (Corn oil). Subjects and Methods. 127 patients with type II diabetes living in Kashan in 2008, 35-50 years old, and 25≤BMI ≤30 were enrolled. ELISA, Glucose Oxidase, spectrophotometry, and Radioimmunoassay methods were used for measurement of serum adiponectin, Fasting Blood Glucose (FBG), HbA1C, and Insulin, respectively. Results. Serum adiponectin increased significantly after EPA consumption in EPA and EPA+E groups. Moreover, FBG, HbA1c, serum insulin and Homeostasis Model HOMA-IR decreased significantly after EPA consumption in the two previously mentioned groups. Conclusions. This study showed that EPA supplementation affects the secretion of adipose tissue, improves the FBS as well as HbA1c values and significantly decreases fasting serum insulin and insulin resistance.

Keywords: Adiponectin, vitamin E, Diabetes, Eicosapentaenoic Acid.

Correspondence: Hassan Nikoueinejad MD, Department of Microbiology amd Immunology, Kashan University of Medical Sciences, Kashan, 8719843996, Islamic Republic of Iran, E-mail: