The International Journal of Romanian Society of Endocrinology / Registered in 1938

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April - June 2016, Volume 12, Issue 2
Endocrine Care

Yalcin MM, Altinova AE, Ozkan C, Toruner F, Akturk M, Akdemir O, Emiroglu T, Gokce D, Poyraz A, Taneri F, Yetkin I

Thyroid Malignancy Risk of Incidental Thyroid Nodules in Patients with Non-Thyroid Cancer

Acta Endo (Buc) 2016, 12 (2): 185-190
doi: 10.4183/aeb.2016.185

Context. Thyroid incidentaloma is a common disorder in endocrinology practice. Current literature regarding the risk of thyroid cancer in incidentalomas found in patients with non-thyroid cancer is limited. Objective. The aim of the present study was to investigate the frequency of thyroid malignancy in thyroid incidentalomas detected in patients with non-thyroid cancer. Design. Case control study. Subjects and Methods. The database of 287 thyroid nodules from 161 patients with a history of nonthyroid cancer followed between 2008 and 2014 were retrospectively evaluated. Results. From 287 thyroid nodules, 69.7 % had a benign final cytology. Thyroid cancer detected in one nodule while follicular neoplasia detected in 4 nodules, atypia of unknown significance (AUS) detected in 10 nodules, Hurthle cell neoplasia detected in 5 nodules and suspicious for malignancy detected in 6 nodules according to fine needle aspiration biopsy results. Metastasis of the non-thyroid cancer to the thyroid gland was detected in 4 nodules. Twenty seven nodules from 15 patients were removed with surgery. There were 3 malignant nodules found after surgery (1 papillary, 1 follicular and 1 medullary cancer). In addition to these three thyroid cancers, two patients with benign nodules had co-incidental thyroid cancer detected after surgery. Finally, 11.1 % of thyroid nodules which underwent thyroid surgery had malignant histopathology except for co-incidental and metastatic cancers. Conclusions. The frequency of thyroid malignancy seems not to be substantially increased in incidental thyroid nodules detected in patients with non-thyroid cancer when these patients were evaluated in nodule-based approach.

Keywords: thyroid cancer, non-thyroid cancer, thyroid nodules

Correspondence: Mehmet Muhittin Yalcin, Gazi University Faculty of Medicine, Endocrinology and Metabolism, Ankara, 06500, Turkey, E-mail: