January - March 2017, Volume 13, Issue 1

Yalin GY, Dogansen SC, Canbaz B, Gul N, Bilgic B, Uzum AK

Incidental Paget’s Disease Disguised as Bone Metastasis in a Patient with Endometrium Carcinoma

Acta Endo (Buc) 2017, 13 (1): 111-114
doi: 10.4183/aeb.2017.111

Paget’s disease is a disorder of aging bone which occurs in the setting of accelarated bone remodelling. In the presented case we discuss the difficulties in the diagnosis of Paget’s disease in a 77 year old patient with coexisting endometrium carcinoma. The patient was initially diagnosed with metastatic bone disease due to endometrium adenocarcinoma when she was admitted to oncology clinic with pelvic pain. Bone scintigraphy with Tc99 and (18) F fluorodeoxyglucose positron emission tomography/CT revealed an increased uptake on the bone lesions which were reported as metastatic bone involvement. Although the (18) F-FDG uptake was much higher than the levels that would generally be anticipated in a case with Paget’s disease, high levels of bone turnover markers indicated further evaluation in the differential diagnosis and the definitive diagnosis of Paget’s disease was established with the pathological evaluation of bone biopsy.

Keywords: Paget’s Disease, Endometrium carcinoma, Bone metastasis.

Correspondence: Gulsah Yenidunya Yalin, Baskent University, Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Altunizade, 34662, Istanbul, Turkey, E-mail: gulsah_y@hotmail.com