The International Journal of Romanian Society of Endocrinology / Registered in 1938

in ISI Thomson Master Journal List

July - September 2017, Volume 13, Issue 3
Endocrine Care

Gursoy AF, Tokmak A, Eroglu S, Yesilyurt H

Effect of Insulin Resistance of the Occurence of Pregnancy in Women Treated Empirically for Unexplained Infertility

Acta Endo (Buc) 2017, 13 (3): 314-321
doi: 10.4183/aeb.2017.314

Context. The detrimental effects of hyperinsulinemia on human ovaries during follicular development process have been shown in various studies, particularly in women with polycystic ovary syndrome. To our knowledge there is no study regarding the effect of insulin resistance (IR) on the intrauterine insemination (IUI) success in women with unexplained infertility (UEI). Objective. To evaluate the effects of IR on the occurrence of pregnancy among infertile women undergoing ovulation induction (OI) with IUI for UEI. Design. Prospective cohort study. Subjects and Methods. 173 patients who met the criteria for UEI and under the age of 35 were included in this study. All women underwent OI with IUI and, subsequently, they were divided into two groups based on the presence of pregnancy. Data reviewed for analysis were demographic, clinical, and laboratory features. Results. There were 37 (21.4%) cycles with pregnancy and 136 (78.6%) cycles without pregnancy. Median infertility duration was significantly lower in the pregnant group when compared with non-pregnants (p=0.018). The mean number of previous cycles per patient was also lower in this group (p=0.028). No significant differences were found between the groups in terms of other variables. Levels of insulin, fasting glucose and HOMA-IR were also similar between the two groups. Conclusions. IR calculated by using HOMA-IR index has no positive or negative effect on the occurrence of pregnancy in women undergoing OI therapy with IUI for UEI.

Keywords: HOMA-IR, intrauterine insemination, unexplained infertility, ovulation induction, pregnancy

Correspondence: Aytekin Tokmak MD, Zekai Tahir Burak Women’s Health Education and Research Hospital, Talatpasa Bulvari, Hamamönü, Altindag/Ankara 06230, Turkey, E-mail: