April - June 2018, Volume 14, Issue 2

Borrayo G, Basurto L, González-Escudero E, Diaz A, Vázquez A, Sánchez L, Hernández-González GO, Barrera S , Degollado JA, Córdova N, Avelar F

Tg/Hdl-C Ratio as Cardio-Metabolic Biomarker even in Normal Weight Women

Acta Endo (Buc) 2018, 14 (2): 261-267
doi: 10.4183/aeb.2018.261

Context. Despite that the Triglycerides/High Density Lipoprotein Cholesterol (TG/HDL-C) ratio has been associated with insulin resistance and cardiovascular disease, some outcomes differ between populations. Objective. The objective of this study was to evaluate the association between TG/HDL-C ratio and cardio-metabolic risk factors in both obese and normal weight women. Design. Cross sectional, from January to December of 2015. Subjects and Methods. Two hundred and fifty three women aged 40 to 60 years. Anthropometric and laboratory measurements were performed. Insulin resistance was measured by the homeostasis model assessment for insulin resistance (HOMA-IR). All participants underwent a Doppler ultrasound to measure intima-media thickness of carotid artery (cIMT). Results. TG/HDL-C ratio correlated with body mass index (r=0.194, p=0.01), and visceral adipose tissue (r=0.193, p=0.002). Additionally, TG/HDL-C correlated with glucose (r=0.367, p=0.001), insulin (r=0.354, p=0.001) and HOMA-IR (r=0.396 p=0.001). TG/HDL-C was associated with prediabetes, Odds Ratio (OR) was 1.83 (95%CI 1.07-3.13) and insulin resistance 3.27 (95%CI 1.78- 6.01), and this risk remains in normal weight women 4.7 (95%CI 1.2-17.81) for prediabetes and 4.38 (95%CI 1.42- 13.84) for insulin resistance. No significant risk for cIMT. Conclusion. A TG/HDL-C ratio ≥ 3.0 is a potential risk factor for prediabetes and insulin resistance in women 40-60 years, even in normal weight women.

Keywords: TG/HDL-C, Insulin Resistance, Carotid Intima-Media Thickness, Prediabetes

Correspondence: María de Lourdes Basurto Acevedo MD, Instituto Mexicano del Seguro Social, Unidad de Investigación en Enfermedades Endocrinas, Av. Cuauhtémoc 330, Colonia Doctores, DF, Mexico, Ciudad de México, 06720, Mexico, E-mail: uiendocrinologia@gmail.com