The International Journal of Romanian Society of Endocrinology / Registered in 1938

in ISI Thomson Master Journal List

July - September 2018, Volume 14, Issue 3
Endocrine Care

Tang W, Chen Q, Chen L, Chen S, Shao X, , Wang X

Favorable Effect of Levothyroxine on Nutritional Status of Patients with Stage 3-4 Chronic Kidney Disease

Acta Endo (Buc) 2018, 14 (3): 338-345
doi: 10.4183/aeb.2018.338

The aim of this study was to analyze the incidence of malnutrition in patients with stage 3-4 chronic kidney disease (CKD) and primary subclinical hypothyroidism and the effect of levothyroxine for improving nutritional status and delaying kidney disease. Patients and Methods. In the study were included 200 patients with stage 3-4 CKD: CKD3 stage group (n=100) and CKD4 stage group (n=100). These patients were further divided into: control group (non-treatment group) group a (n=65) and experiment group (treatment group) group b (n=135) according to their levothyroxine treatment. The CKD3 stage group is divided into c3 (n=35) and e3 (n=65), and CKD4 group is divided into c4 (n=30) and e4 (n=70) groups. Results. Upon treatment of subclinical hypothyroidism with levothyroxine, nutritional indicators of patients are improved, and the weight, left and right-hand grip strength, hemoglobin (HB), serum albumin are higher compared to control. After levothyroxine treatment, eGFR in the treatment group increased with each time point, while in the control group it could be seen a significant decrease. This effect was more robust in the CKD3 group than in the CKD4 group. In conclusion, levothyroxine treatment can delay the progression of kidney diseases with more efficacy in stage 3 patients.

Keywords: Chronic kidney disease, levothyroxine, nutritional status

Correspondence: Weidong Tang MD, The First People’s Hospital of Fuyang, Intensive care unit, Hangzhou, 311400, China, E-mail: