The International Journal of Romanian Society of Endocrinology / Registered in 1938

in ISI Thomson Master Journal List

October - December 2018, Volume 14, Issue 4
Endocrine Care

Arhire LI, Mihalache L, Padureanu SS, Nita O, Gherasim A, Constantinescu D, Preda C

Changes in Bone Mineral Parameters after Sleeve Gastrectomy Relationship with Ghrelin and Plasma Adipokin Levels

Acta Endo (Buc) 2018, 14 (4): 498-504
doi: 10.4183/aeb.2018.498

Context. Metabolic surgery is currently the most efficient treatment for obesity, but concern is raised about the possible long-term nutritional side effects. Bone metabolism is often adversely affected after surgery, but literature data are contradictory. Objective. The aim of this study was to evaluate the evolution of bone mass parameters in the first year after laparoscopic sleeve gastrectomy in relation to anthropometric and body composition parameters and specific hormones of obesity. Design. We conducted a prospective study on 75 patients with obesity that underwent metabolic surgery over a course of 18 months at our center, with a follow-up period of 12 months. Subjects and Methods. All patients underwent a complex preoperative assessment and were required to return for medical follow-up at 6 and 12 months after surgery. Each visit included anthropometric parameters, DEXA and determination of specific hormonal parameters. Results. We noticed a significant improvement in anthropometric and body composition parameters after surgery. The value of adiponectin presented a significant increase after surgery and leptin showed a significant decrease at 6 and 12 months postoperative; ghrelin level decreased postoperative compared to preoperative, but without statistical significance. We observed no reduction in BMD after surgery, but a significant improvement in BMC at 12 months after surgery compared to preoperative. Ghrelin negatively correlated to BMD preoperative. Conclusions. Despite the significant alterations in anthropometric, body composition and hormonal parameters, we found no negative effect on BMD and BMC in our study population.

Keywords: laparoscopic sleeve gastrectomy, ghrelin, obesity, bone mineral density, bone mineral content.

Correspondence: Lidia Iuliana Arhire MD, “Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Bd. Independentei nr. 1, Iasi, 700012, Romania, E-mail: