The International Journal of Romanian Society of Endocrinology / Registered in 1938

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July - September 2019, Volume 15, Issue 3
Case Report

Croitoru A, Dinu I, Herlea V, Becheanu G, Grasu M, Lupescu I, Dima SO, Buica F, Dumitrascu T, Lungulescu C, Croitoru VM, Tanase A, Negru SM, Gramaticu IM

Large Cell Metastatic Pancreatic Neuroendocrine Carcinoma Treated with Somatostatin Analogues - Case Report and Literature Review

Acta Endo (Buc) 2019, 15 (3): 390-397
doi: 10.4183/aeb.2019.390

We report the case of a 55-year-old-male with a large cell metastatic pancreatic neuroendocrine carcinoma treated for 14 months with lanreotide autogel having a stable disease (SD) and not responding to chemotherapy. The somatostatin analogues (SSA) were introduced after an episode of diarrhea and controlled the disease. Progression-free survival (PFS) as determined by Computerized Tomography (CT) scans was obtained for 14 months. After more than a year, the patient’s health state deteriorated along with progressive disease. The capecitabine-temozolomide regimen was challenged, but after three cycles, a rapid clinical decline was noted. Conclusion. This unexpected event (diarrhea) in the course of the disease could represent the beginning of carcinoid syndrome. While the lanreotide autogel helped the episode of diarrhea pass, it also helped gain control over the disease itself.

Keywords: Nueorendocrine tumor, Large cell pancreatic carcinoma, lanreotide autogel

Correspondence: Vlad Mihai Croitoru MD, Fundeni Clinical Institute, Oncology, 258 Fundeni Rd, 2nd District, Bucharest, 077086, Romania, E-mail: