April - June 2020, Volume 16, Issue 2

Tanase A, Nemescu D, Popescu R, Toma BF, Matasariu RD, Onofriescu M

FSH Receptor and FSH Beta Chain Polymorphism Involvement in Infertility and Endometriosis Disease

Acta Endo (Buc) 2020, 16 (2): 142-147
doi: 10.4183/aeb.2020.142

Objectives. The purpose of this study was to evaluate the association between the follicle-stimulating hormone (FSH) receptor (c.-29G>A) and FSH beta chain (c.- 280G>T) polymorphisms and endometriosis in Romanian women. Material and methods. We performed the polymorphic analysis of the FSH receptor gene and FSH beta chain in 44 patients with endometriosis and 34 controls. Genomic DNA was obtained from peripheral blood and polymorphisms were investigated using restriction fragment length polymorphism analysis (RFLP). Results. There were no significant differences in genotype frequencies of FSH receptor gene between endometriosis patients and controls. For the heterozygous type of the FSH receptor polymorphism (c.-29G>A) we did not find a significant difference in its frequency between patients with minimal/mild and moderate/severe endometriosis (p = 0.136). Also, the FSH beta chain (c.- 280G> T) polymorphism frequency was not significantly associated with the severity of endometriosis (p = 0.966). Conclusions. FSH receptor and FSH beta chain polymorphisms do not seem to influence the severity of endometriosis, but they could be correlated with female infertility (primary or secondary), therefore further studies are required to debate this topic.

Keywords: FSH receptor, LH receptor, FSH receptor, endometriosis, infertility, polymorphism.

Correspondence: Dragos Nemescu MD, “Cuza Voda” Hospital, Maternal Fetal Medicine Department, Cuza Voda 34, Iasi, 700038, Romania, E-mail: dragos.nemescu@umfiasi.ro