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ACTA ENDOCRINOLOGICA (BUC)
The International Journal of Romanian Society of Endocrinology / Registered in 1938in ISI Thomson Master Journal List
Acta Endocrinologica(Bucharest) is live in PubMed Central


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Acta Endocrinologica (Buc)
Vukomanovic V, Matovic M, Djukic A, Ignjatovic V, Vuleta K, Djukic S, Vukomanovic IS
The Role of Tumor-Seeking Radiopharmaceuticals in the Diagnosis and Management of Adrenal Tumors
Acta Endo (Buc) 2020, 16 (3): 316-323doi: 10.4183/aeb.2020.316
Context. The variety of tumor-seeking
radiopharmaceuticals, which are currently in clinical use,
may have a potential role as imaging agents for adrenal gland
tumors, due to physiological characteristics of this organ.
Objective. The purpose of this study was to evaluate
the diagnostic potential of 99mTc-HYNIC-TOC, 99mTc(V)-
DMSA, and 99mTc-MIBI in the assessment of adrenal tumors,
by correlating with imaging findings and histopathologic
results.
Design. The research is designed as a crosssectional
prospective study.
Patients and method. The study included 50
patients with adrenal tumors (19 hormone-secreting
and 31 nonfunctioning) and 23 controls without adrenal
involvement. In all patients, single-photon emission
computed tomography (SPECT) was performed, using
qualitative and semiquantitative analysis. The tumor to nontumor
tracer uptake was conducted by using a region-ofinterest
technique. Adrenal to background (A/B) ratio was
calculated in all cases.
Results. 99mTc-HYNIC-TOC scintigraphy showed
a high statistical significance between A/B ratios, while
other two tracers resulted in a lower sensitivity, specificity
and accuracy. Futhermore, 99mTc-HYNIC-TOC could have a
high diagnostic yield to detect adrenal tumors (the receiveroperating-
characteristic curve analysis, A/B ratio cut-off
value of 8.40).
Conclusion. A semiquantitative SPECT analysis
showed that 99mTc-HYNIC-TOC is a highly sensitive tumorseeking
agent for the accurate localization of adrenal tumors.
Keywords: scintigraphy, adrenal tumor, 99mTc(V)-DMSA, 99mTc-HYNIC-TOC, 99mTc-MIBI.
Correspondence: Ivana Simic Vukomanovic, MD, PhD, University of Kragujevac, Serbia, Faculty of Medical Sciences, 69 Svetozara
Markovica street, 34000 Kragujevac, Serbia, E-mail: drivanasimic@gmail.com