The International Journal of Romanian Society of Endocrinology / Registered in 1938

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Acta Endocrinologica(Bucharest) is live in PubMed Central

July - September 2020, Volume 16, Issue 3
Endocrine Care

Akici N, Onal ZE, Gurbuz T, Sag C, Kilinc S

Atherogenic Indices in the Assessment of Cardiovascular Disease Risk in Children with Obesity and Subclinical Hypothyroidism

Acta Endo (Buc) 2020, 16 (3): 334-338
doi: 10.4183/aeb.2020.334

Background. The frequency of subclinical hypothyroidism (SH) in patients with obesity is increased compared with the normal population. However, data on the risk of cardiovascular disease (CVD) in patients with SH are still scarce. Lipid parameters are strong predictors of early CVD. We aimed to investigate the role of lipid indices in predicting CVD risk compared to conventional lipid components. Methods. A total of 220 euthyroid obese children (EU) and 90 obese children with SH were included in the study. All data were collected from hospital files. Lipid indices were evaluated. Atherogenic index of plasma (AIP), cardiac risk ratio (CRR) and atherogenic coefficient (AC) were calculated. AIP>0.24, CRR>5 ve AC>3 were considered as cardiovascular risk criteria. Results. The presence of SH increased the risk of higher AIP and the risk of CRR, compared to euthyroid obese children. Conclusion. Subclinical hypothyroidism in obese children may cause dislipidemia carrying a high cardiovascular disease risk.

Keywords: Atherogenic coefficient, atherogenic index of plasma, cardiac risk ratio, obesity, subclinical hypothyroidism.

Correspondence: Narin Akici MD, Haydarpasa Numune Education and Research Hospital, Department of Pediatrics, Tibbiye Cad. No: 23 Selimiye Üsküdar, 34668, Istanbul, Turkey, E-mail: