July - September 2020, Volume 16, Issue 3

Grigorescu F, Lautier C

How Geneticists Contribute to Understanding of Covid-19 Disease Pathogenicity

Acta Endo (Buc) 2020, 16 (3): 346-352
doi: 10.4183/aeb.2020.346

Human populations are faced to the COVID-19 pandemic due to the emerging SARS-CoV-2 coronavirus originating from Wuhan (China) and with dramatic Public Health consequences. Despite periods of panic, the scientific community demonstrated an incredible innovation potential and energy ending up in one year with new vaccines to be used in population. Researchers are interrogating on how individual genetic differences contribute to the diversity of clinical manifestations or ethnic and geographic disparities of COVID-19. While efforts were spent to understand mechanistically the infectious potential of the virus, recent progresses in molecular genetics and bioinformatics allowed the characterization of viral sequence and construction of phylogeographical maps of viral dispersion worldwide. These data will help understanding epidemiological disparities among continents and ethnic populations. Much effort was also spent in analyzing host genetics by studying individual genes involved in innate and immune responses or explaining pathogenesis of comorbidities that complicate the fate of elderly patients. Several international consortia launched already Genome wide Association Studies (GWAS) and whole genome sequencing strategies to identify genetic markers with immediate application in patients at risk of respiratory failure. These new genetic data are important not only for understanding susceptibility factors for COVID-19 but they also contain an important message of hope for mankind warranting our survival and health.

Keywords: COVID-19, SARS-CoV2, single nucleotide variation (SNV), genome wide association study (GWAS).

Correspondence: Florin Grigorescu MD, PhD, Scientific Editor, Institut du Cancer de Montpellier (ICM), Department of Clinical Research and Innovation (DCRI), E-mail: florin.grigorescu@icm.unicancer.fr