October - December 2020, Volume 16, Issue 4

Balta F, Cristescu IE, Mirescu AE, Balta G, Tofolean IT

Effect of a Multinutrient Complex on Retinal Microcirculation in Diabetic Patients Investigated Using an Adaptive Optics Retinal Camera

Acta Endo (Buc) 2020, 16 (4): 389-395
doi: 10.4183/aeb.2020.389

Context. Alimentary supplements may have beneficial effects on retinal microvasculature in diabetic patients. Objective and Design. State-of-the-art imaging techniques were used to assess retinal microcirculation in diabetic patients in an observational study before and after 3 months treatment with a multinutrient complex including resveratrol, vitamins D3, C, E, essential fatty acids, trace elements (zinc and copper) and macular pigments (lutein and zeaxanthin)-Resvega. Subjects and Methods. Fifteen subjects were included in this study. Adaptive optics ophthalmoscopy was used to measure the parameters of temporal retinal arterioles. Optical coherence tomography angiography was employed to assess foveal avascular zone and vessel densities of the superficial capillary plexus, deep capillary plexus and choricapillary plexus. Results. After 3 months of treatment, there was a statistically significant median decrease in wall-to-lumen ratio (p=0.0001). The same tendencies were noticed for wall thickness values (p=0.008) and wall cross sectional area values (p=0.001). On the other side, no significant changes were noticed concerning the OCTA parameters. Conclusions. Resvega seems to have a beneficial effect on the retinal arterioles in diabetic patients.

Keywords: diabetic retinopathy, resveratrol, adaptive optics ophthalmoscopy, optical coherence tomography angiography.

Correspondence: Irina-Elena Cristescu MD, “Carol Davila” University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474, Bucharest, Romania, E-mail: cristescu.irina@gmail.com