ACTA ENDOCRINOLOGICA (BUC)

The International Journal of Romanian Society of Endocrinology / Registered in 1938

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Acta Endocrinologica(Bucharest) is live in PubMed Central

October - December 2020, Volume 16, Issue 4
Endocrine Care


Onder CE, Kuskonmaz SM, Koc G, Firat S, Omma T, Taskaldiran I, Gokbulut P, Culha C

Factors that Affect the Glycemic Control Achieved by Switching to Insulin Degludec/ Aspart in Insulin-Treated Patients with Type 1 and Type 2 Diabetes in a Real-World Setting: a Non-Interventional, Retrospective Cohort Study

Acta Endo (Buc) 2020, 16 (4): 443-448
doi: 10.4183/aeb.2020.443

Background. Insulin degludec/aspart (IDegAsp) is a co-formulation with IDeg and IAsp. Different insulin regimens may be switched to IDegAsp. In this study, we aimed to find out the effect of switch to IDegAsp on glycemic control and whether the basal characteristics and treatment modalities of the patients affect the change in glycemic control brought by switch to IDegAsp. Methods. We retrospectively analyzed the records of 78 patients whose insulin therapies (basal+bolus, premixed analogues or basal only) were switched on a 1:1 unit basis to IDegAsp±bolus insulin. Oral antidiabetic agents (OADs) given were recorded. At the end of 12th and 24th week, total insulin doses of patients and HbA1c were compared to the baseline. Results. There was a statistically significant decrease at HbA1c at 12 weeks (1.4%; p<0.001). There was not a significant difference in HbA1c between the OAD added group and the group with no new OADs(p=0.1). Basal insulin dose was not statistically different from baseline, whereas bolus insulin dose was significantly lower (p=0.007). At the end of 24 weeks the decrease in HbA1c level from baseline was preserved. Conclusion. Regardless of the baseline insulin regimen, diabetes type and oral antidiabetic drugs given, HbA1c is significantly lowered after switching to IDegAsp.

Keywords: insulin degludec/aspart, diabetes mellitus, co-formulation.

Correspondence: Cagatay Emir Onder MD, Ankara Training and Research Hospital, Dept. of Endocrinology and Metabolism, Saglik Bakanligi Ankara Egitim ve Arastirma Hastanesi Sakarya Mh. Ulucanlar Cd. No:89 Altindag, Ankara, 06230, Turkey, E-mail: drcagatayemironder@gmail.com