The International Journal of Romanian Society of Endocrinology / Registered in 1938

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Acta Endocrinologica(Bucharest) is live in PubMed Central

January - March 2020, Volume 16, Issue 1
Endocrine Care

Beksac MS, Fadiloglu E, Tanacan A

Perinatal Outcomes of Pregnant Women with Type 1 Diabetes Mellitus: Comparison of Multidose Injection and Continuous Subcutaneous Insulin Infusion

Acta Endo (Buc) 2020, 16 (1): 53-58
doi: 10.4183/aeb.2020.53

Objective. To evaluate obstetric and neonatal outcomes of patients with type 1 diabetes mellitus (T1DM) and compare multidose injection (MDI) and continuous subcutaneous insulin infusion (CSII). Study Design. Retrospective study of 53 pregnant patients with T1DM reaching at least 24th gestational week. Results. Fourteen patients (26.4%) hospitalized for insulin dose regulation. Ten patients had hypertensive diseases. Perinatal mortality occurred in 2 neonates owing to cardiac malformations. Neonatal hypoglycemia, small for gestational age, large for gestational age, and neonatal jaundice were demonstrated in 8, 4, 12 and 19 newborns, respectively. Sixteen newborns were admitted to the NICU for various reasons. Congenital malformations were detected in 7 newborns (6 cardiovascular and 1 central nervous system anomaly). Despite lack of statistical significance, total daily insulin doses were higher in the MDI group than in the CSII group with doses of 62 IU (18–166) and 51 IU (20–114), respectively (p=0.119). Gestational and perinatal outcomes also showed no statistical significance. However, all congenital abnormalities and perinatal deaths occurred in the MDI group. Conclusion. T1DM in pregnancy is a challenging problem in terms of having better obstetric and perinatal results. CSII may be used safely instead of MDI in appropriate patients.

Keywords: diabetes mellitus, pregnancy

Correspondence: Erdem Fadiloglu MD, Hacettepe University, Department of Obstetrics and Gynecology, Ankara, 06320, Turkey, E-mail: