The International Journal of Romanian Society of Endocrinology / Registered in 1938

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July - September 2021, Volume 17, Issue 3
Endocrine Care

Yilmaz Oztekin GM, Genc A, Arslan S

Vitamin D Deficiency is a Predictor of Mortality in Elderly with Chronic Heart Failure

Acta Endo (Buc) 2021, 17 (3): 358-364
doi: 10.4183/aeb.2021.358

Context. The prevalence of both heart failure and vitamin D deficiency increases with age and is associated with poor outcome in the elderly. Objectives. We aimed to investigate the relationship between all-cause mortality and vitamin D deficiency in elderly patients with chronic heart failure. Design. It is a retrospective, observational crosssectional study. Median follow-up time was 497 days. Subjects and Methods. 302 patients aged ≥65 years heart failure patients was categorized into tertiles based on the 25-hydroxy-vitamin D levels. Clinical and laboratory parameters were evaluated according to tertiles. Hospitalization rates and overall survival were compared between tertiles. Independent predictors of all cause mortality were defined. Results. Patients with low vitamin D tertile were mostly women (p=0.001), and had a worse NYHA functional class (p=0.005). During follow-up, deaths were more frequent in the first tertile (p = 0.001). All-cause mortality increased significantly with decreasing vitamin D tertiles (from third tertile 7.9%, to 11.9%, to 26%; log rank test p=0.003). No significant difference was observed at the composite endpoint of mortality or HF hospitalizations (P=0.451). Multivariate analysis supported that low vitamin D concentration was an independent predictor of all causes of mortality (HR 0.93; 95% CI 0.89-0.97; p=0.004). Conclusions. Low vitamin D levels were independent predictors of all-cause mortality in the elderly population with chronic heart failure.

Keywords: Heart failure, Vitamin D, Mortality, Elderly.

Correspondence: Gülsüm Meral Yilmaz Öztekin MD, University of Health Sciences, Antalya Education and Research Hospital, Department of Cardiology. Varlik Neighborhood. Kazim Karabekir Road, Antalya, 07100, Turkey, E-mail: