The International Journal of Romanian Society of Endocrinology / Registered in 1938

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October - December 2021, Volume 17, Issue 4
General Endocrinology

Tomov DG, Levterova BA, Mihaylova VN, Troev DM, Miteva MZ, Orbetzova MM

Serum Zonulin Levels in Hypothyroid and Euthyroid Patients with Hashimoto’s Thyroiditis – a Pilot Study

Acta Endo (Buc) 2021, 17 (4): 449-454
doi: 10.4183/aeb.2021.449

Context. Human zonulin is a protein that regulates the intercellular tight junctions in various tissues and organs of the human body. Hashimoto’s thyroiditis (HT) is one of the most common endocrine autoimmune disorder, but the role of increased intestinal permeability in its pathogenesis is still being studied. Objective and design. This pilot cross-sectional study investigates serum zonulin concentration in adults with Hashimoto’s thyroiditis and assesses the relationship between zonulin levels, clinical hormonal and immunological characteristics. Subjects and methods. A group of 62 adults with HT participated in this study and were divided into three groups: hypothyroid (n=33) euthyroid (n=25) and hyperthyroid (n=4). Serum zonulin was determined using an ELISA method. Results. Age, gender and BMI were different between groups (hypothyroid and euthyroid ones). Serum zonulin values ranged from 2.6 to 198.0 ng/mL in participants. A direct positive correlation was found between serum zonulin levels and weight and BMI (r = 0.351, p = 0.008 and r = 0.236, p = 0.05, respectively). Conclusions. There is no correlation between zonulin and thyroid hormones or autoantibodies in Hashimoto thyroiditis patients. There is a difference in zonulin levels between the studied groups, but they are not statistically significant.

Keywords: Hashimoto’s thyroiditis (HT), zonulin, increased intestinal permeability (IIP).

Correspondence: Desislav G. Tomov, Medical University of Plovdiv, Faculty of Pharmacy, Department of Bioorganic chemistry, 120 Bratya Bukston str., Plovdiv, 4004, Bulgaria, E-mail: