The International Journal of Romanian Society of Endocrinology / Registered in 1938

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October - December 2021, Volume 17, Issue 4
Clinical review/Extensive clinical experience

Vancea A, Serban O, Fodor D

Relationship between Osteopontin and Bone Mineral Density

Acta Endo (Buc) 2021, 17 (4): 509-516
doi: 10.4183/aeb.2021.509

Recent studies suggest that osteopontin (OPN) could be used as an early marker for the diagnosis of bone disorders. Considering the contradictory opinions in the literature, the objective of this systematic review is to analyse the current information regarding the relationship between OPN and bone mineral density (BMD), which represents an important process in the development of osteoporosis. We performed a literature search of clinical trials using the PubMed database, published between 1999-2020, and identified 7 studies that were eligible for analysis. The eligibility criteria were based on studies that analysed the relationship between osteopontin and bone mineral density on human subjects. Conclusion: serum OPN levels might be used as a biomarker of the early diagnosis of osteoporosis in postmenopausal women, with or without osteoporotic vertebral fractures.

Keywords: osteopontin, bone mineral density, BMI, osteoporotic fracture

Correspondence: Adelina Vancea MD, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2nd Internal Medicine Department, 2 Clinicilor street, Cluj-Napoca, 400000, Romania, E-mail: