The International Journal of Romanian Society of Endocrinology / Registered in 1938

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October - December 2021, Volume 17, Issue 4
Endocrine Care

Turan U, Kilavuz H, Irkorucu O

Clinical Features of Hypercalcemic Crisis in Primary Hyperparathyroidism

Acta Endo (Buc) 2021, 17 (4): 493-497
doi: 10.4183/aeb.20212.493

Context. Primary hyperparathyroidism related hypercalcemic crisis (PHHC) is a condition that may result in fetal course. So, the early diagnosis and treatment of these patients are important Objective. This study aimed to investigate the clinical features for hypercalcemic crisis (HC) by comparing the groups with and without primary hyperparathyroidism related calcemic crisis. Design. All patients operated with primary hyperparathyroidism (PH) diagnosis in a single clinic between March 2015 and March 2020 were included in this retrospective study. Subjects and Methods. 119 patients included the study.Patients with serum calcium (Ca) level > 14 mg/dl were regarded as HC and the patients were divided into two groups as HC and non-HC. These two groups were compared for demographic data, preoperative biochemical parameters, preoperative localization studies, histopathological assessment and postoperative results. Results. Serum Parathormone (PTH), Ca, Alkaline phosphatase (ALP) and creatinine values among preoperative biochemical parameters were higher in the HC group than the non-HC (p<0.005). The hyper-functional parathyroid size of the patients in the HC group was also bigger compared to non-HC (p<0.05). No difference was observed in the demographic and histopathological data, preoperative localization studies and postoperative results of the two groups (p>0.05). Conclusions. PH is usually an elective operation and PHCC treatment should be relatively more urgent as it can be mortal. Higher HC occurrence possibility should be considered in PH patients with high serum PTH, ALP and creatinine values and large tumor diameters and those patients should be prioritized for treatment.

Keywords: hypercalcemia, hypercalcemic crisis, hyperparathyroid crisis, primary hyperparathyroidism, parathyroidectomy.

Correspondence: Umit Turan MD, Adana City Training and Research Hospital General Surgery Clinic Yuregir, Adana, Turkey, E-mail: