The International Journal of Romanian Society of Endocrinology / Registered in 1938

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January - March 2022, Volume 18, Issue 1
Notes & Comments

Ucak R, Turkyilmaz Mut D, Kaya C, Yilmaz Ozguven B, Kabukcuoglu F, Uludag M

Is Repeat FNAB Necessary For Thyroid Nodules with ND / UNS Cytology?

Acta Endo (Buc) 2022, 18 (1): 127-133
doi: 10.4183/aeb.2022.127

Context/Objective. The standard approach is to perform repeat FNAB (rFNAB) in thyroid nodules with nondiagnostic (ND) / insufficient (UNS) cytology. However, due to the nature of these nodules, recurrent FNABs may also be insufficient. Therefore, by comparing the clinicalradiological- pathological parameters of nodules with a definite diagnosis of excision, we questioned the possibility of patient management without rFNAB. Methods. Clinical-radiological parameters of 275 nodules belonging to 264 patients in the ND/UNS aspiration group with definite pathological diagnosis after surgery were determined. Under the guidance of these parameters, those with and without rFNAB were compared. Results. The incidence of malignancy was found to be significantly higher in nodules without rFNAB compared to nodules with rFNAB (p = 0.036). In addition, the incidence of malignancy in BC-1 nodules without rFNAB was significantly higher than in nodules with rFNAB result also BC-1 (p = 0.009). In all cases, nodule size smaller than 10 mm and border irregularity were found to be statistically significant for malignancy (p <0.020, p <0.002). When looking at the distribution of rFNAB results, a significant correlation was observed with female gender, solid component, hypoechogenicity, border irregularity and halo loss around the nodule in patients with BC-4,5,6 cytology results (respectively, 0.005 / 0.031 / 0.001 / 0.012 / 0.004). Conclusion. rFNAB did not show the expected effect in ND / UNS nodules. We recommend direct surgical excision without rFNAB for nodules with border irregularity, solid structure, halo loss and hypoechogenicity, which should be considered more important in female patients.

Keywords: Thyroid, Bethesda Category, ND/UNS, Repeat FNAB.

Correspondence: Ramazan Ucak MD, Pathology Department, University of Health Sciences, Sisli Hamidiye Etfal Health Application and Research Center, 19 May District, Etfal Street, Istanbul, 34700, Turkey, E-mail: