The International Journal of Romanian Society of Endocrinology / Registered in 1938

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April - June 2022, Volume 18, Issue 2
General Endocrinology

Can M, Kocabas M, Karakose M, Alsancak Y, Yerlikaya FH, Caliskan Burgucu H, Cordan I, Kadiyoran C, Kulaksizoglu M, Karakurt F

New Biomarkers to Predict Cardiovascular Risk in Patients with Adrenal Incidentaloma; Irisin and Nesfatin-1

Acta Endo (Buc) 2022, 18 (2): 150-155
doi: 10.4183/aeb.2022.150

Objective. In our study, we aimed to investigate the levels of irisin, nesfatin-1 and the relationship between levels of these relatively new molecules with cardiometabolic risk markers; carotid intima-media thickness (CIMT), epicardial adipose tissue (EAT) thickness in patients with nonfunctional adrenal incidentaloma (NFAI). Materials and Methods. Patients with NFAI (n=59) and age, sex and body mass index-matched healthy control subjects (n=59) were enrolled in this study. Serum glucose, insulin, C-reactive protein (CRP), lipid, irisin and nesfatin-1 levels and echocardiographic CIMT and EAT thickness measurements were performed in patients and controls. Results. The irisin level was 17.58 ± 4.38 pg/mL in the NFAI group, significantly higher (p<0.001) than 14.03 ± 4.03 pg/mL in the control group. Nesfatin-1 level was significantly lower in the NFAI group 194.98 ± 119.15 pg/ mL ((p < 0.001)) versus 303.48 ± 200.78 pg/mL in the control group. A positive correlation was found between irisin and nesfatin-1 levels and CIMT and EAT thickness in the NFAI group. Conclusions. In our study, we found that irisin level was higher and nesfatin-1 level was lower in patients with NFAI, and both irisin and nesfatin-1 levels were associated with CIMT and EAT thickness in NFAI patients.

Keywords: Adrenal incidentaloma, irisin, nesfatin-1.

Correspondence: Mustafa Can MD, Necmettin Erbakan University, Meram Medical Faculty Hospital, Konya, 42020, Turkey, E-mail: