The International Journal of Romanian Society of Endocrinology / Registered in 1938

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April - June 2022, Volume 18, Issue 2
General Endocrinology

Erdem H, Canakci E, Kaya Y, Ozbilen M, Ankarali H

Relation of Apelin, Tumor Necrosis Factor Alpha and Claudin-5 to Body Mass Index in Cholecystectomies

Acta Endo (Buc) 2022, 18 (2): 156-163
doi: 10.4183/aeb.2022.156

Objective. The aim of this study was to investigate the relationship of Claudin-5, Apelin, Tumor Necrosis Factor Alpha (TNF-α) expression, and body mass index (BMI) of cholecystectomies. Materials and methods. Sixty-eight paraffin embedded cholecystectomy specimens diagnosed as chronic cholecystitis were collected in the Pathology Department of the Training and Research Hospital between 2015-2017. The samples were stained with Apelin, Claudin-5 and TNF-α. The immunohistochemical study was carried out using the system in an automatic staining machine. Results. There was a significant positive correlation between BMI and TNF-α staining (p=0.010). This result indicated that the degree of staining increased together with BMI. When age, BMI, and the other biochemical parameters were evaluated, a significant correlation was found between BMI and blood glucose only (p=0.029); correlations of BMI with the other parameters were not statistically significant. Conclusion. Although there is no relationship between inflammation and BMI with Claudin-5 and Apelin in this study, there is a significant relationship between BMI and TNF-α.

Keywords: Body Mass Index, Apelin, Claudin, TNF-a.

Correspondence: Havva Erdem MD, Ordu University, Department of Pathology, Cumhuriyet Campus Cumhuriyet Mahallesi PK: 52200 Altinordu/ Ordu, Turkey, E-mail: