The International Journal of Romanian Society of Endocrinology / Registered in 1938

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July - September 2022, Volume 18, Issue 3
Case Report

Saraf P, Bharti JN, Elhence P, Pandey H

Giant Adrenal Ganglioneuroma and Myelolipoma: A Rare Case of Collision Tumor

Acta Endo (Buc) 2022, 18 (3): 379-382
doi: 10.4183/aeb.2022.379

Background. An adrenal collision tumor is a rare entity. We present a rare combination of giant adrenal ganglioneuroma (GN) and myelolipoma. GN is a rare benign tumor of the adrenal medulla that originates from primitive neural crest cells, while myelolipoma is a benign tumor of the adrenal cortex comprising of mature adipose tissue and blood components. Case Report. We present a case of a 52-year-old male who presented with generalized body swelling with episodes of vomiting and diarrhea. There was no history of abdominal pain or any significant history. Routine laboratory investigations and endocrine workup were within normal limits. MRI was performed for unexplained symptoms, and which revealed a solid homogeneous mass measuring 9x7x4.5cm arising from the adrenal gland. A diagnosis of myxoid adrenocortical neoplasm was suggested, and laparoscopic left adrenalectomy was performed based on imaging findings. The final diagnosis of coexisting giant adrenal GN with myelolipoma was made on histopathological examination, which was further confirmed by immunohistochemistry. Conclusion. Ganglioneuroma coexistence with myelolipoma is a rare finding in the adrenal gland. Therefore, histopathology is imperative in such cases for a definitive diagnosis.

Keywords: Adrenal cortex neoplasm, Adrenal Medulla neoplasm, abdominal mass.

Correspondence: Jyotsna Naresh Bharti, All India Institute of Medical Sciences, Department of Pathology, Mangalagiri, Guntur, India, E-mail: