July - September 2022, Volume 18, Issue 3

Singh Y, Bharti JN, Chaoudhary GR

Oncocytic Adrenocortical Carcinoma in a Young Patient

Acta Endo (Buc) 2022, 18 (3): 383-386
doi: 10.4183/aeb.2022.383

Context. Adrenocortical carcinoma (ACC) is a rare neoplasm with an aggressive course and poor prognosis. The worldwide incidence is about 0.5 to 2 cases per million population per year. Oncocytic adrenocortical carcinoma is a rare histopathological variant of ACC with only a few reported cases in the literature. Case report. We report a case of an oncocytic variant of adrenocortical carcinoma in a 21-year-old male patient who presented with a left adrenal mass. Imaging studies confirmed a large left adrenal mass with involvement of the left renal vein and inferior vena cava. Endocrine workup showed mildly elevated serum cortisol levels. Discussion. Oncocytic AAC is a rare histopathological variant of ACC, as well as a rare subgroup of oncocytic adrenal neoplasms Hormonally active or functioning adrenocortical carcinomas most commonly secrete cortisol whereas co-secretion of multiple steroid hormones is a rare phenomenon. Conclusions. Surgery remains the mainstay of treatment, but most of the patients present late with large masses and eventually become unsuitable for curative resection.

Keywords: Adrenocortical carcinoma, Oncocytic adrenocortical neoplasm, Oncocytic adrenocortical carcinoma, Cushing’s syn.

Correspondence: Jyotsna Naresh Bharti, All India Institute of Medical Sciences, Department of Pathology, Mangalagiri, Guntur,India, E-mail: jyotsnamamc@gmail.com