January - March 2022, Volume 18, Issue 1

Sharma M, Modi A, Goyal M, Sharma P, Purohit P

Anti-Thyroid Antibodies and the Gonadotrophins Profile (LH/FSH) in Euthyroid Polycystic Ovarian Syndrome Women

Acta Endo (Buc) 2022, 18 (1): 79-85
doi: 10.4183/aeb.2022.79

Context. The current study aimed to determine association of anti-TPO with LH/FSH in PCOS women. Design. Current case control study included 33 diagnosed PCOS women and 32 age matched healthy women and were analysed for body mass index (BMI) and waist to hip ratio (WHR), fasting blood glucose (FBG), free T3 (FT3), free T4 (FT4), Thyroid stimulating hormone (TSH), dehydroepiandrostenedione (DHEA-S), total testosterone, follicular stimulating hormone (FSH), luteinizing hormone (LH) and anti thyroperoxidase antibodies (anti-TPO). Data was statistically analysed by Student’s t – test and Pearson’s correlation analysis. Results. Of the total PCOS women, 45% were obese and 34.37% had raised anti-TPO. The biochemical profile of obese PCOS women showed significantly raised FBG (p<0.0001), LH (p<0.0001), Testosterone (p<0.0001) and DHEA-S (p=0.0021) as compared to non-obese PCOS women. The LH/FSH ratio was significantly raised in PCOS women as compared to control (p<0.0001). Pearson’s correlation analysis showed a significant association of anti-TPO with FBS, testosterone, LH and LH/FSH in obese PCOS and with Testosterone and LH in non-obese PCOS women using SPSS 21. Conclusion. The current study shows a high prevalence of AITD in euthyroid PCOS women and suggests a strong link of euthyroid obese PCOS women to autoimmunity due to the hyper-anderogenism and a higher LH/FSH ratio.

Keywords: PCOS, Autoimmune thyroiditis, Obesity, Anti-TPO, LH/FSH

Correspondence: Purvi Purohit MD, All India Institute of Medical Sciences, Department of Biochemistry, Basani Phase II, Jodhpur, 342005, India, E-mail: dr.purvipurohit@gmail.com