January - March 2023, Volume 19, Issue 1

El Hasbani G, Megahed A, Cassetta M

When Tophaceous Gout Involves Multiple Organs: Challenges and Solutions

Acta Endo (Buc) 2023, 19 (1): 131-132
doi: 10.4183/aeb.2023.131

Uncontrolled chronic gout can lead to deposition of monosodium urate crystals, better known as tophi. Such depositions can involve several organ systems, including unusual locations such as the vertebrae. Nevertheless, certain complications, such as hypercalcemia, can arise because of tophi. Despite an aggressive intervention, hypercalcemia might not resolve spontaneously, as long as an ongoing inflammatory process secondary to gouty tophi is taking place. Herein, we present the case of a 62-year-old man with a long history of gouty tophi who presented for back pain and was found to have spinal cord involvement with PTH-independent hypercalcemia which only resolved with pegloticase therapy.

Keywords: Gout, hypercalcemia, Tophi.

Correspondence: Georges El Hasbani MD, "St Vincent's" Medical Center, 2800 Main Street, Bridgeport, 06606-4292, United States, E-mail: george.hasbany@lau.edu