January - March 2023, Volume 19, Issue 1

Chen Y, Zhang J, Li L, Liu C, Li P

Serum Omentin-1 Level is Associated with the Aggregation of Cardiovascular Risk Factors in Adolescents

Acta Endo (Buc) 2023, 19 (1): 19-24
doi: 10.4183/aeb.2023.19

Objective. The existing studies involving omentin-1 have mainly focused on relationships with single cardiovascular risk factor. Whether omentin-1 is associated with the aggregation of cardiovascular risk factors has not been reported. We investigate the relationship between the serum omentin-1 level and aggregation of cardiovascular risk factors in adolescents. Subjects and Methods. A total of 741 young students, 11–16 years of age, were enrolled using a stratified cluster sampling method. The participants were given a questionnaire survey and underwent a physical examination. The aggregation of cardiovascular risk factors was defined as two or more cardiovascular risk factors occurring simultaneously in the same individual. Results. Partial correlation analysis suggested that serum omentin-1 level was significantly correlated with waist circumference (R=-0.086, P=0.019) and Body Mass Index (R=-0.096, P=0.009). Logistic regression analysis showed that as the serum omentin-1 level increased, the risk of aggregation of cardiovascular risk factors decreased. Cardiovascular risk factors which were most closely associated with a decrease in the serum omentin-1 level were obesity calculated by Body Mass Index (OR=0.988, P=0.043) and central obesity calculated by waist circumference (OR=0.993, P=0.012). Conclusions. The serum omentin-1 level in adolescents is inversely associated with the aggregation of cardiovascular risk factors. Waist circumference and Body Mass Index are factors most closely associated with a decrease in the serum omentin-1 level.

Keywords: Omentin-1, aggregation of cardiovascular risk factors, adolescent, obesity

Correspondence: Ping Li MD, Shengjing Hospital of China Medical University, Department of Endocrinology, Shenyang, 110004, China, E-mail: scizhong@163.com