The International Journal of Romanian Society of Endocrinology / Registered in 1938

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July - September 2023, Volume 19, Issue 3

Minhas R, Shekhda KM, Palan M, Anthony K, Vogazianou A, Rossi M

Rhabdomyolysis Secondary to Rapid Correction of Hyponatremia in a Patient with Psyhcogenic Polydipsia

Acta Endo (Buc) 2023, 19 (3): 345-348
doi: 10.4183/aeb.2023.345

Patients with chronic schizophrenia and psychosis are more prone to develop hyponatremia. Hyponatremia could be due to medications e.g. antidepressants/antipsychotics or secondary to psychogenic polydipsia. They often present with altered consciousness, seizures and falls. Rapid correction of hyponatremia in patients with psychogenic polydipsia has been associated to cause rhabdomyolysis, an under-recognized yet serious condition which if left untreated can result in various complications e.g. acute kidney injury, electrolyte abnormalities. We report a case of young patient who had background illness of schizophrenia and presented to department with severe hyponatremia secondary to psychogenic polydipsia and was eventually diagnosed as case of rhabdomyolysis due to rapid correction of hyponatremia. Objective of case report is to highlight the correct diagnosis of underlying cause of hyponatremia and challenges associated with managing rhabdomyolysis with IV fluids that can result in worsening of hyponatremia, hence emphasizing the importance of close monitoring of sodium levels and measurement of creatine kinase in any patient who presents with severe hyponatremia, particularly in the presence of other risk factors for rhabdomyolysis and consideration of careful fluid administration strategies in relation to the relative onset and risk of over-correcting hyponatremia

Keywords: Hyponatremia, Rhabdomyolysis, Psychogenic polydipsia.

Correspondence: Raisa Minhas, Hillingdon Hospital NHS Trust, Diabetes Endocrinology, Whittington Hospital, Magdala Ave, London, N19 5NF, United Kingdom of Great Britain and Northern Ireland, E-mail: