October - December 2023, Volume 19, Issue 4

Taskaldiran I, Gokbulut P, Koc G, Firat S, Omma T, Kuskonmaz SM, Culha C

Case of Hyponatremia Due to Pituitary Metastasis of Lung Cancer

Acta Endo (Buc) 2023, 19 (4): 501-504
doi: 10.4183/aeb.2023.501

Context. Hyponatremia is a common electrolyte abnormality. Objective. We report a patient who presented with hyponatremia and diagnosed as small cell lung cancer metastatic to hypothalamus and pituitary. Case report. A 68 year old male patient was admitted with fever and cough and pneumonia was considered. Serum sodium level was 113 mmol/L. Syndrome of in appropriate ADH (SIADH) is considered. Thyroid function tests and cortisol levels pointed out a central deficiency in both axes. Pituitary MRI was performed and a hypothalamic and pituitary mass were observed. Prednisolone therapy was started followed by L thyroxine replacement. A chest computer tomography (CT) was taken 2 weeks later revealed a mass lesion. Bronchoscopic biopsy was performed and histopathological diagnosis of the tumor was reported as small cell lung cancer. Result. Many mechanisms were considered as the cause of hyponatremia in our patient. SIADH, secondary adrenal insufficiency and secondary hypothyroidism due to pituitary metastasis are possible causes. Conclusion. The reason of hyponatremia is sometimes complex. When the underlying causes of hyponatremia are not evaluated in detail, many diagnoses can be missed.

Keywords: hyponatremia, piuitary metastasis, cancer.

Correspondence: Isilay Taskaldiran MD, Ankara Training and Research Hospital, Dept. of Endocrinology and Metabolism, Saglik Bakanligi Ankara Egitim ve Arastirma Hastanesi Sakarya Mh. Ulucanlar Cd. No:89 Altindag, Ankara, 06230, Turkey, E-mail: dr.isilaymenekse@hotmail.com.